6 Choline Bitartrate

January 14, 2021

Choline Bitartrate is a natural salt that the body produces in small amounts but could be ingested as a supplement. When choline combines with tartaric acid, it forms Choline Bitartrate. As a supplement, Choline Bitartrate falls under synthetic nootropic, a precursor to acetylcholine. Choline itself is an important essential nutrient. But, binding with tartaric acid increases bioavailability. More so, it is the most recognized form of choline. 

History of Choline bitartrate

Adolph Strecker discovered choline in 1862. Yet, the Food and Nutrition Board of the National Institute of Medicine declared it in 1998 in the US. 

Choline bitartrate acts as a source of choline. The supplement belongs to the class of nootropics known as intermediates. But it is the best source of choline and acetylcholine. They provide high levels of acetylcholine in the brain. This is used as a kicker to enhance the effect of racetams. 

How does it work?

Choline bitartrate supplement has several mechanisms of action. More precisely, choline participates in several critical biochemical pathways. Choline bitartrate has several ways it affects the brain positively. But three main effects as the main mechanisms of action are: 

Boosts acetylcholine production 

The supplements boost acetylcholine, a well-known neurotransmitter-tied brain function, and memory. , it is a precursor to acetylcholine. It improves the efficiency of communication between neurons in the brain. Thus, its importance in neural signaling boosts mental clarity, cognitive processing, and learning. 

Increase production of phospholipids

The body needs choline to synthesize Phosphatidylcholine and sphingomyelin. They are vital for cell membrane makeup. All plants and animal cells need choline to preserve their structural integrity. Besides, Phosphatidylcholine is a key component of conditional reservoirs of choline. This factors in acetylcholine production.  

Functions of Choline Bitartrate supplement

When you take this supplement, it acts as the main source of choline in the body. The primary function of choline in the body includes: 

Boost memory

Supplementing with choline bitartrate, as shown in several studies, improves memory. Besides, research shows poor memory in people with choline deficiency. Thus, Choline Bitartrate supplementation in such people boosts memory. 

Memory loss due to aging factors can be treated using a choline bitartrate. 

Mental Stimulation

Choline Bitartrate supplement improves mood and brain energy. Supplementing with choline bitartrate can make a huge difference when feeling down and less alert. Also, it increases the production of acetylcholine. 

Improves Sleep

The choline bitartrate supplement provides high levels of choline. It helps initiate rapid eye movements (REM). There are five stages of sleep. REM is considered to have the most impact when it comes to memory formation. It stores what was learned throughout the day. 

REM contributes to restful sleep through its impact on the stimulus barrier. Therefore, the brain ignores the noise and other input from the environment. It allows one to sleep without interruption. 

Help with Alzheimer’s-Type Dementia

Choline Bitartrate supplementation reduces the effect of Alzheimer-type dementia. It improves some cognitive performance functions such as:

  • Auditory
  • Visual word recognition


Helpful with Bipolar Disorder

Choline bitartrate supplementation showed improvement in mood symptoms of Bipolar Disorder. This was evidenced in a small human study where patients were treated with choline bitartrate. The study also showed a rise in the concentration of choline-containing compounds in the basal ganglia region of the brain. 

How to take Choline bitartrate?

Choline is available in the body in small amounts. It is available for consumption in foods and dietary supplements. Choline bitartrate is one of the best choline sources. 

Choline food sources include: 

  • Brussel sprouts
  • Cauliflower
  • Salmon
  • Beef
  • Liver
  • Eggs 
  • Chickpeas
  • Navy beans
  • Split peas
  • Goat milk
  • Chicken breast
  • Turkey

Breast milk also contains a high amount of choline. For supplementation, choline bitartrate is available in capsule, tablets, and powder form. The recommended daily dosage of choline bitartrate supplements differs in accordance to: 

  • User’s age
  • Gender
  • Genetic makeup

The standard dose of Choline bitartrate supplement is 500 mg to 3,000 mg each day. You can also take the supplement twice a day with food. 

Higher doses can be taken as it is a water-soluble version of choline. Any excess amount of this choline source will cross the blood-brain barrier. 

Note many nootropic stacks on the market contain choline bitartrate formula. Even some brand name vitamins contain the Choline Bitartrate. 

Side Effects

The supplement is non-toxic, but high intake can result in toxicity with too much choline in the body. 

The most common side effect includes: 

  • Sweating
  • Vomiting
  • Fishy body odor
  • Dizziness
  • Digestive upset
  • Diarrhea

If you experience trouble sleeping, stop using Choline Bitartrate supplementations. 


The choline bitartrate supplement is suitable for anyone looking for a high-quality source of choline. The supplement improves body composition and reduces body fat levels. 

As a Nootropic, choline bitartrate provides cognitive-enhancing benefits. The ingredient boosts brain function. You can buy high-quality choline bitartrate “stacks” in the US market.

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