Everything you need to know about Alpha-GPC

December 8, 2020

Alpha GPC is a choline compound that occurs naturally in the brain. It is also made in the laboratory for use as a medicine and a supplement. But natural sources of Alpha GPC only contain trace amounts. Yet, the body can make it from choline-rich food. To boost the natural level of choline, you can eat foods like beef liver, eggs, chicken, whole grains, and soybean.

You can also buy Alpha GPC as a supplement. In the US, Alpha GPC is a dietary supplement, but in some European countries, alpha-GPC is a prescription medication. 

How does Alpha-GPC work?

Alpha GPC supplements provide the body with high levels of choline. Thus, it increases the brain chemical acetylcholine. The brain chemical is significant for memory and learning function.

Increasing Acetylcholine Production

Acetylcholine handles many chemical message movements in the body. It is useful for learning and muscle construction, which forms the brain brawn link.

Alpha GPC supplement delivers choline to the brain faster, increasing the production of acetylcholine. High levels of choline let the body convert it to acetylcholine. Later, it contributes to a host of downstream effects.

Acetylcholine is used by the hippocampus, which is responsible for creating memories.

Role of Acetylcholine in the brain include:

  • Support your working memory.
  • Enhance your linguistic skills.
  • Improve critical thinking.
  • Increase creativity.


Also, the chemical compound handles memory coordination and mobility. 

Benefits of Alpha-GPC supplement

Helps with dementia

Older folks often suffer from dementia. The condition is characterized by progressive cognitive decline and memory loss. As a result, this causes brain damage, low blood flow, among others.

Alpha-GPC supplements shield the brain from damage and protect it from cognitive decline, independent of the trigger and cause.

Cognitive Impairment

Alpha-GPC improves attention and memory. Compared to choline or lecithin, Alpha-GPC is better with significantly fewer side effects.

A study on Alpha GPC benefits examined nootropic effects and brain protection. The results showed enhanced mental performance. It also showed reduced cognitive decline caused by inadequate blood supply, brain damage, and seizures.

Alzheimer’s Disease

The condition is caused by a bunch of mutated proteins that kill neurons. They deplete the neurotransmitter acetylcholine. As a result, Alzheimer’s disease leads to an array of cognitive issues.

Alpha GPC supplementation showed improvement in all symptoms of the condition. Also, the supplement boosted the effects of Alzheimer’s standard treatment donepezil. Therefore, the supplement offers cognition-enhancing effects.

Athletic Performance

Alpha GPC supplement enhances athletic performance. In healthy young people, it stimulates muscle building by increasing growth hormone. Alpha GPC supplement has gained popularity among bodybuilders, athletes, and weightlifters.

A study done using alpha-GPC supplement showed improved speed, power, and pull force. The supplement had more potent effects on the lower body. A lower dose of alpha-GPC (250mg) enhanced vertical jump power.

Growth hormone

Alpha GPC supplements boost growth hormone production and fat burning capabilities. 

Helps with stroke

Alpha-GPC supplements boost recovery from Stroke and TIA. The patients recover from cognitive disabilities and can function better.

How to take Alpha GPC

The recommended dosage is 500-1000mg each day. For starters, calculate the current choline intake from the diet. It should be around 200mg per day. 

Alpha-GPC supplements usually have 40% choline by weight. Thus a 250mg capsule delivers 100mg of choline. On the other hand, 1g of Alpha-GPC supplements powder gives 400mg of choline. But Alpha-GPC 50% powder gives 200mg choline.

You can take the daily Alpha-GPC at different times of the day, but with a gap of 4-6 hours. That way, you can meet the daily recommended intake. The supplement has a half-life of 4-6 hours. You need to take it throughout the day rather than in one go.

In some cases, exceeding the daily dosage limit shows better results. The body breaks down choline at different rates. According to Dr. Steven Zeisel, men should be taking 850mg/day of choline. Know your limit to prevent too much Acetylcholine in the brain. You may suffer adverse Alpha-GPC side effects.

Side effects

A headache or brain-fog indicates excess dosage. Although the effect won’t last long, it is a good indication of your “limit.”

Alpha-GPC is safe when used right for up to 6 months. While you can experience Alpha GPC side effects, the effects disappear soon. 

Possible side effect includes:

  • heartburn
  • headache
  • skin rash
  • dizziness
  • insomnia
  • confusion
  • injection site redness


Alpha GPC side effects on pregnancy and breastfeeding are unknown. Thus, pregnant and breastfeeding women should avoid its use.


Alpha GPC supplement enhances athletic performance. It stimulates muscle building through a boost in growth hormone. It can also treat and reverse cognitive decline. It is available as a supplement in many vitamin stores. In the US, Alpha GPC is best purchased in powder form. 

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