Aniracetam is a supplement that belongs to a special class of drugs known as synthetic nootropics, which means it does not occur naturally in the body. Hence it has to be taken as a supplement. A Nootropic is a drug or substance which is believed to enhance cognitive function.
Aniracetam was discovered in the 1970s by F. Hoffmann-La Roche AG, a Swiss multinational healthcare company. The company patented it in 1978 as a brain booster and stimulant.
It belongs to a class of nootropics known as racetam nootropics, including similar drugs like piracetam. The chemical name is 1-p-anisoyl-2-pyrrolidinone, which is a real tongue-twister.
Aniracetam affects the brain positively in several ways, but below mentioned three main effects had been proposed as the main mechanisms of action:
Most of the drug is metabolized within the brain into its active metabolites, N-anisoyl-GABA (70-80%), 2-pyrrolidinone, and p-anisic acid (20–30%). These active metabolites positively modify a group of receptors within the brain called AMPA receptors.
The AMPA receptors act as a gateway that shuttles glutamate within the brain cells. Over time the amount of glutamate the receptors allow within the brain is reduced due to a natural process called desensitization.
The active metabolites of Aniracetam bind to the receptor and prevent this process from happening. This increases the amount of glutamate available within the brain. This increase in glutamate levels increases cognitive function, memory and is also neuroprotective.
Aniracetam has been found to increase the concentration of dopamine and serotonin in certain sections of the brain. These include parts of the brain involved in social interaction and mood stability.
The overall effect is an increase in sociability and improved mood. This also has some anxiolytic properties, which means it can help reduce anxiety.
Acetylcholine is a naturally occurring substance found within the body and, most importantly, in the brain. Falling acetylcholine levels are associated with a decrease in cognition, memory function, and mood stability.
Reduced acetylcholine levels are one of the major contributing factors in Alzheimer’s disease. Aniracetam boosts acetylcholine production within the brain, replenishing our natural stores and warding off the gradual mental decline associated with aging.
That is why Aniracetam is a great supplement for those who are struggling with Alzheimer’s disease or are genetically predisposed to the condition. For adequate acetylcholine production, it’s best to combine Aniracetam with a choline supplement.
Aniracetam is sold as a tablet, capsule, or powder. Most tablets and capsules are usually 750 mg each. The recommended dose is 1500 mg per day but can be safely raised to 3000 mg per day if needed.
It is usually taken as two 750 mg doses, typically one in the morning and one in the early afternoon. Avoid taking Aniracetam at night due to its stimulant properties, which may disturb your sleeping patterns.
For optimal results, take Aniracetam with a choline supplement. Also, since the drug is fat-soluble, it should be taken with meals that contain healthy fats like extra virgin olive oil, unrefined coconut oil, or omega-3 oils.
Aniracetam is generally well-tolerated and should have no serious side effects. However, some rare side effects may include:
These usually occur when unnaturally high doses of Aniracetam is taken. Headaches are a common sign of choline deficiency and can be prevented by supplementing Aniracetam with adequate choline amounts.
Aniracetam is an effective and safe cognitive supplement with numerous benefits. The drug is sold under prescription within Europe but can be purchased online by several USA vendors as a non-dietary supplement. Aniracetam is most effective when combined with a healthy diet, exercise, and adequate sleep.